Cisplatin resistance and pd-l1

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August undefined, 2024

WebMay 1, 2024 · Since PD-L1 expression protects tumor cells from pro-apoptotic drugs, we hypothesized that the PD-1/PD-L1 axis might contribute to the acquisition of resistance … WebApr 14, 2024 · Moreover, subsequent experiments revealed that HAT1 upregulates PD-L1 expression through the action of the transcription factor BRD4, which binds to the promoter of PD-L1. ... Notably, during the development of cisplatin resistance, many changes at the genetic and epigenetic levels are evident . HAT1 has been shown to contribute to …

KIFC1 Is Associated with Basal Type, Cisplatin Resistance, PD-L1 ...

WebNevertheless, the role of PD-L1 in chemoresistance development is not fully understood. In the current study, we aim to clarify the interaction of miR-519d-3p and PD-L1 in the development of cisplatin resistance. Immunohistochemistry, quantitative reverse-transcription polymerase reaction, and Western blot were used to evaluate PD-L1 … WebNov 15, 2024 · Abstract. Accumulating evidence indicates that a ligand of programmed cell death receptor-1 (PD-L1) participates in the progression and recurrence of multiple malignancies, including osteosarcoma. Nevertheless, the role of PD-L1 in chemoresistance development is not fully understood. greatest common factor song

Cisplatin promotes the expression level of PD-L1 in the ...

WebApr 14, 2024 · Autophagy Influences Hypoxia, Chemoresistance, and Stem-like Phenotype in Breast Cancer It is known that cancer stem cells are a significant contributor to the development of chemoresistance in breast cancer [ 88, 89, 90, 91 ]. Autophagy enables the survival of CSCs under hypoxia in the tumor microenvironment [ 92 ]. WebDec 19, 2024 · The differential expression of PD-L1 at the mRNA and protein levels in the chemosensitive and chemoresistant cell lines strongly implicate PD-L1 in the development of cisplatin resistance.... WebNov 30, 2024 · Cisplatin may also cause upregulation of tumor cell PD-L1, which may in part explain the additive antitumor activity of cisplatin and PD-L1/PD-1 blockade. This … greatest common factors of 60

Gastric cancer derived mesenchymal stem cells promoted DNA …

MicroRNA‐519d‐3p antagonizes osteosarcoma resistance against cisplatin ...

http://mars.gmu.edu/handle/1920/13265?show=full WebJul 28, 2024 · PD-L1, the ligand of PD-1, expresses universally and increases in malignant cells [ 8 ]. Recent studies indicated that both PD-1 and PD-L1 contribute to cisplatin … flipkart iphone 13 price historyWebCisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness seems to be due to the unique properties of cisplatin, which enters cells via multiple … flipkart iphone 13 offer

"WebMay 28, 2024 · PD-L1 is critical for tumor cell escape from immune surveillance by inhibiting T cell function via the PD-1 receptor. Accumulating evidence demonstrates that anti-PD-L1 monoclonal antibodies might potently enhance antitumor effects in various tumors, but the effect of PD-L1 on colorectal cancer stem cells (CSCs) remains unclear. " - Cisplatin resistance and pd-l1

Cisplatin resistance and pd-l1

The Molecular Basis and Therapeutic Aspects of Cisplatin Resistance …

WebApr 13, 2024 · Consequently, miR-196a released from exosomes can confer cisplatin resistance to cancer cells by novel binding targets, CDKN1B and ING5, demonstrating that miR-196a could be a potential predictor ... WebOct 13, 2024 · For example, cisplatin resistance sometimes correlates with the presence of wild type TP53 . ... High expression of CD274/PD-L1 combined with low expression of the histone deacetylase, ...

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WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the epithelial to mesenchymal transition. Conclusions We identified gene signatures in resistant TNBC subtypes indicative of mechanisms of cisplatin. WebNov 4, 2024 · Our results suggested blockage of the cell-intrinsic PD-1/PD-L1 maybe the reason why combined PD-1/PD-L1 inhibitors and cisplatin had an increased efficacy in cervical cancer cells.

WebJul 26, 2024 · Chemotherapy resistance can be ... and incubated for 5 min. Cell-ID 103 Rh was chosen for cell viability in lieu of Cell-ID cisplatin, ... significant increases in splenic PD-L1 + CD11b + Gr-1 ...

WebPD-L1 in cancer cells, PD-L1 in TILs, and PD-1 in TILs took up 59.1%, 47.0%, and 60.6%, respectively. The data indicated that both dMMR and PD-L1 overexpression resulted … WebGastric cancer derived mesenchymal stem cells promoted DNA repair and cisplatin resistance through up-regulating PD-L1/Rad51 in gastric cancer 设为首页收藏本站

WebCisplatin may also cause upregulation of tumor cell PD-L1, which may in part explain the additive antitumor activity of cisplatin and PD-L1/PD-1 blockade. This information will help in interpreting results of ongoing clinical trials combining these agents, and for comparison of potential future therapeutic combinations for the treatment of head ...

WebOct 22, 2024 · Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment. greatest common factor spanishWeb14 hours ago · Cisplatin treatment does not change the level of expression of EGFR and PD-L1. ... EVs, namely the tetraspanins CD9 and CD81 which are common EV markers … flipkart iphone 13 pro maxWeb14 hours ago · The results indicate that in contrast to erlotinib and cisplatin, osimertinib treatment increased a subset of the HER2 and PD-L1 positive EV population. However, the average expression of the two proteins on individual EVs was found to … flipkart iphone 13 scamWebSep 9, 2016 · Here we report that cell-intrinsic expression of PD1 and PD-L1, two immune checkpoints, is required for sustained expansion of SCLC cells under cisplatin … greatest common factor sum of whole numbersWebCisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells Immune tolerance is one of the leading causes of chemotherapy resistance in carcinoma cases. greatest common factor story problemsWebOct 21, 2024 · Knockdown of KIFC1 by siRNA increased the sensitivity to cisplatin in BC cells. Kaplan-Meier analysis indicated that prognosis was poor among KIFC1 -positive BC patients treated with cisplatin-based chemotherapy. Immunohistochemistry showed that KIFC1 -positive cases were associated with PD-L1-positive cases. greatest common factor step by stepWebPD-L1 increases resistance to radiation or cisplatin by stabilizing NBS1, BRCA1, and other proteins that facilitate the repair of DNA damage ( 5 ). PD-L1 also diminishes IFN-β cytotoxicity by inhibiting an IFN-β–induced STAT3/caspase-7–dependent pathway ( 6 ). flipkart iphone 14 pro max