Dithiolethiones
WebAnethole dithiolethione and other dithiolethiones for the treatment of conditions associated with dysfunction of monoamine neruotransmission Abstract The present disclosure relates to dithiolethione derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel ... Webdithiolethiones compounds, particularly (4-phenyl-1,2-dithiole-3-thione), exhibit the biological activity against Staphylococcus aureus. Antibacterial activity showed value ranged from 1.02 to 1.428 mg/ml (MIC). All of the tested dithiolethiones and antibiotics were inactive against Escherichia coli and Pseudomonas aeruginosa, except
Dithiolethiones
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WebThis patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results. WebJan 1, 2010 · Dethionation of dithiolethiones to 1,2-dithiole-3-ones was accomplished by mercury(ii)-promoted hydrolysis. A preliminary investigation of the dithiolethiones and dithiole-3-ones as inhibitors of ...
WebThe invention relates to dithiolethiones derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture ... WebThe invention relates to dithiolethiones derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture ...
WebBackground: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system characterized by demyelination of neurons and neurodegeneration. Current MS therapies ameliorate inflammatory damage but are unable to address the degenerative aspects of the disease. Objective: In this report, we evaluate the ability of amide-based … WebNov 11, 2008 · Abstract. Dithiolethiones are a well-known class of cancer chemopreventive agents; the key mechanism of action of dithiolethiones involves activation of Nrf2 …
WebMay 11, 2024 · Dithiolethiones are five-membered sulfur-containing cyclic scaffolds that exhibit antioxidative, anti-inflammatory, antithrombic and chemotherapeutic activities. …
WebDithionite. The unusual structure of the dithionite anion. It has a remarkably long sulfur-sulfur bond. A ball-and-stick model of the dithionite ion. The dithionite is the oxyanion with the … jelle drijfhoutWebSep 28, 2024 · There are plenty of sulfur-containing molecules in the food chain, e.g., amino acids such as cysteine and methionine, lipoic acid (an essential cofactor of four mitochondrial enzyme complexes), allicin (the active flavor compound in crushed garlic), and bioactive compounds like dithiolethiones. laia manresaWebJun 24, 2010 · The dithiolethiones activate Nrf2, a key stimulator of cytoprotective defence against carcinogens and oxidants, and Nrf2 in turn is essential for induction of Phase 2 enzymes by these compounds. Bladder cancer is the fourth commonest cancer in men and the eighth commonest in women, and its incidence continues to rise. jelle de graaf jinekWebAll 17 dithiolethiones were then tested for their ance in humans has been examined. ability to inhibit acute hepatotoxicity by aflatoxin B1 Oltipraz [2] and other dithiolethiones are potent inducers of (AFB1), which previously has been shown to be an inter- enzymes involved in the maintenance of the reduced gluta- mediate predictor of ... laia marsalWebDithiolethiones are lipophilic, organosulfur compounds that activate the Nrf2 transcription factor causing an upregulation of various phase II antioxidant enzymes. A disubstituted … lai amara j mdWebdithiolethione (plural dithiolethiones) ( organic chemistry ) Any (especially cyclic) dithiole derivative of a thione Retrieved from " … jelledotWebMay 11, 2024 · Dithiolethiones are lipophilic, organosulfur compounds that activate the Nrf2 transcription factor causing an upregulation of various phase II antioxidant enzymes. … jelle doosje lcr