Klf11 heart
WebSep 24, 2013 · In KRAS-mutant pancreatic cancer cells, activated ERK phosphorylates KLF11, disrupting KLF11–SIN3A interactions and impairing TGFβ-induced growth inhibition 11,108 . Thus, both KLF10 and KLF11 ... WebFeb 27, 2024 · A, Compared to wild-type (WT) mice, conventional Klf11 knockout mice and vascular smooth muscle cell (SMC)–specific Klf11 knockout mice have higher levels of TF in the arterial wall; steady-state levels of circulating TF + microvesicles (MVs) are similar in WT and conventional Klf11 knockout mice.
Klf11 heart
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WebJan 3, 2024 · Objective— Mutations in Krüppel like factor-11 (KLF11), a gene also known as maturity-onset diabetes mellitus of the young type 7, contribute to the development of diabetes mellitus. KLF11 has anti-i. ... Eur Heart J. 2005; 26:682–688. doi: 10.1093/eurheartj/ehi094 Crossref Medline Google Scholar; 46. WebFeb 7, 2014 · Neve et al. (2005) sequenced the KLF11 gene in 190 probands of families with early-onset type II diabetes mellitus and identified a SNP (A349S; 603301.0001) in affected members of a 4-generation family and another SNP (T220M; 603301.0002) in affected members of 2 unrelated multigenerational families. Neither SNP was found in 313 …
WebJan 10, 2014 · It is found that KLF11 was increased following H/R and reached the highest level with 24 h hypoxia followed by 12 h reoxygenation, suggesting that KLf11 may be … WebKLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression Authors Wenying Liang 1 2 , Haocheng Lu 1 , Jinjian Sun 1 , Guizhen Zhao 1 , Huilun Wang 1 2 , Yanhong Guo 1 , Daniel Eitzman 1 , Y Eugene Chen 1 , Yanbo Fan 3 4 , Jifeng Zhang 1
WebJul 19, 2024 · Krüppel like factor 11 (KLF11), a transcription factor involved in diabetes, inhibits EC inflammation via regula... Abstract 265: Endothelial Krüppel Like Factor 11 Inhibits Abdominal Aortic Aneurysm Arteriosclerosis, Thrombosis, and Vascular Biology Background: Endothelial Cell (EC) dysfunction contributes to many vascular diseases. WebRole of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function Bernadette Nevea, Martin E. Fernandez-Zapicob, Vered Ashkenazi-Katalanc, Christian Dinaa, Yasmin H. Hamidd, Erik Jolye, Emmanuel Vaillanta, Yamina Benmezrouaa, Emmanuelle Duranda, Nicolas Bakahera, Valerie Delannoya, Martine …
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WebDec 13, 2024 · KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion. Taken together, our findings identify a novel anti-hypertrophic and anti-fibrotic role of KLF11, and KLF11 activator may serve as candidate drug for heart failure patients. mikes coachesWeb強迫性障害と抗精 神 病薬による欠陥症候群(NIDS)の合併例に抗精 神 病薬中止とSSRIが奏効した一例 [Case of obsessive-compulsive disorder associated with neuroleptics-induced deficit syndrome (NIDS): successfully treated by discontinuation of neuroleptics followed by SSRI.]. 精 神 神 経学雑誌 [Seishin Shinkeigaku Zasshi] (in Japanese). 107 (7): 667–673. mike scmitt induction speechWebJan 10, 2014 · KLF11 is expressed ubiquitously and participates in diabetes and regulates hepatic lipid metabolism. However, the role of KLF11 in cardiovascular system is largely … new world 144 fpsWebFeb 1, 2024 · KLF11 is a pancreas-enriched transcription factor that has elicited significant attention from researchers due to its role as a negative regulator of exocrine cell growth both in vitro and in vivo [ 2 ]. Previous studies have shown that KLF11 is involved in the pathophysiological process of diabetes development [ 3 – 5 ]. new world 1700sWebglucose levels induced KLF11 mRNA expression in beta cells (Fig. 1B). KLF11, as a member of the Sp1 KLF family, has been predictedtobindtoeitherGC … new world 1650WebMay 18, 2024 · KLF11 promotes glucose-induced insulin secretion in pancreatic β-cells, and basic studies have also clarified the extensive role of KLF11 in glucose homeostasis. At the molecular level, KLF11 mutants allow the suppressor mSin3A binding to KLF11 and ultimately inhibit insulin transcription. new world 150-200 armoringWebJan 10, 2014 · KLF11 is expressed ubiquitously and participates in diabetes and regulates hepatic lipid metabolism. However, the role of KLF11 in cardiovascular system is largely … mikesclothes dot com