Slc13a3 and succinate
WebOct 10, 2013 · The substrates carried by the SLC13 transporters include the citric acid cycle intermediates citrate, succinate, and α-ketoglutarate. Plasma concentrations of these … WebJan 28, 2014 · This presentation will focus on the di- and tricarboxylate transporters, NaDC1 (SLC13A2), NaDC3 (SLC13A3) and NaCT (SLC13A5). The substrates of these transporters are metabolic intermediates of the citric acid cycle, including citrate, succinate and α-ketoglutarate, which can exert signaling effects through specific receptors or affect ...
Slc13a3 and succinate
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WebSep 6, 2024 · It has been reported that Slc13a3 is a Na + /dicarboxylate cotransporter and it is associated with the Krebs cycle occurring in mitochondrial matrix for transporting … WebSep 6, 2024 · Mechanistically, Slc13a3, a direct target of Slug in LSCs, restricts the self-renewal of LSCs and markedly prolongs recipient survival. Genetic or pharmacological inhibition of SLUG or forced...
WebJan 1, 2012 · The SLC13 gene family is comprised of structurally related membrane transport proteins with unique substrate specificities (Markovich, 2001; Markovich & Murer, 2004).They can be divided into the following two distinct groups: the Na +-sulfate (NaS) cotransporters and the Na +-carboxylate (NaC) cotransporters (Table 1).This review will … WebApr 1, 2013 · The SLC13 family comprises five genes ( SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8–13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes.
WebDec 13, 2024 · Background: SLC13A3 gene encodes the Na + /dicarboxylate cotransporter 3 (NaDC3), which locates on the plasma membrane and is mainly expressed in kidney, … WebSLC13A3. Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene. [5] [6] …
WebJan 1, 2024 · In mouse bone marrow-derived macrophages (BMDMs), succinate acts as a stabilizing signal for the transcription factor hypoxia-inducible factor 1 alpha (HIF-1 α) via prolyl hydroxylases enzyme (PHD) inhibition, to induce transcription of interleukin (IL)-1β and drive a proinflammatory phenotype [3 ].
WebJan 11, 2024 · Functional studies performed on HEK293T cells transiently transfected with wild-type and mutant SLC13A3 indicated that the missense mutations caused a marked reduction in the capacity to transport αKG, succinate, and NAA. Interpretation. SLC13A3 deficiency causes acute and reversible leukoencephalopathy with marked accumulation … rmm tools that allow smartcard redirectionWebDec 13, 2024 · Background: SLC13A3 gene encodes the Na + /dicarboxylate cotransporter 3 (NaDC3), which locates on the plasma membrane and is mainly expressed in kidney, astrocytes and the choroid plexus. It imports four to six carbon dicarboxylates together with three Na + ions into the cytosol. sn536 dchst a-aWebMammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and … sn556s16icWeb(SLC13A3), and NaCT (SLC13A5). The substrates of these transporters are metabolic intermediates of the citric acid cycle,including citrate,succinate,and α-ketoglutarate, which can exert signaling effects through specific receptors or can affectmetabolicenzymesdirectly.TheSLC13transportersare important for regulating … sn 53 hs 41 teWebDec 30, 2024 · In this review, we summarize the non-metabolic signalling mechanisms of succinate, fumarate, itaconate, 2-hydroxyglutarate isomers (d-2-hydroxyglutarate and l-2-hydroxyglutarate) and acetyl-CoA,... sn550 2tb tbwWebNov 7, 2024 · The basolateral membrane of the tubular cells express a high-affinity concentrative uptake system for these dicarboxylates, known as NaDC3 (Na + /dicarboxylate cotransporter 3 or SLC13A3) [21,22], which accumulates dicarboxylates in cells by uptake from blood and these divalent anions serve as the exchangeable substrates for OAT4 in … rm multi academy trustsWebJan 5, 2024 · Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [ (house mouse)] Gene ID: 114644, updated on 5-Jan-2024 Summary Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. rmm triangle